Adverse Drug Reactions

Adverse drug reactions can be considered a form of toxicity or enhanced drug effects that occur during appropriate use (eg, when drug metabolism is temporarily inhibited by a disorder or another drug). In the US, 3 to 7% of all hospitalizations are due to adverse drug reactions. ADRs occur during 10 to 20% of hospitalizations; about 10 to 20% of these ADRs are severe. Incidence of death due to ADRs is unknown; suggested rates of 0.5 to 0.9% may be falsely high because many of the patients included had serious and complex disorders. Incidence and severity of adverse drug reactions vary by patient characteristics (eg, age, sex, ethnicity, coexisting disorders, genetic or geographic factors) and by drug factors (eg, type of drug, administration route, treatment duration, dosage, and bioavailability. Incidence is higher with advanced age and polypharmacy

Market Analysis: Geographically, North America held the largest market share of the global market, owing to large production of new drugs development, along with increasing number of clinical trials has led to further need pharmacovigilance of drugs, resulting in higher demand in this region. Moreover, ADRs, contribute to more than 100,000 deaths in the United States annually and most top 10 leading causes of death. Regulator bodies are developing active surveillance approaches to assess the risk of medicine in the post-market phase of the novel products. The growth of pharmacovigilance market in Europe is also attributed to growing number of adverse drug reactions, and growing demand in end-use industry.

Related Industry: Fresenius KabiIcon plcDana-Farber Cancer InstituteColumbia UniversitySyneos Health ClinicalNYU Langone HealthEdwards LifesciencesGenmab.

Associations and Societies: Drug Information Association, Drug-Safe AustraliaPharmacoepidemiology and Drug SafetyInternational Society of PharmacovigilanceDrug Information AssociationDrug Safety Association.

  • Acute and chronic adverse drug events
  • Classification of various adverse drug reactions
  • Mechanism of adverse drug reactions
  • Assessing and reporting adverse drug reactions
  • Expected and un-expected drug reactions and its reporting

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